LnRiLWZpZWxke21hcmdpbi1ib3R0b206MC43NmVtfS50Yi1maWVsZC0tbGVmdHt0ZXh0LWFsaWduOmxlZnR9LnRiLWZpZWxkLS1jZW50ZXJ7dGV4dC1hbGlnbjpjZW50ZXJ9LnRiLWZpZWxkLS1yaWdodHt0ZXh0LWFsaWduOnJpZ2h0fS50Yi1maWVsZF9fc2t5cGVfcHJldmlld3twYWRkaW5nOjEwcHggMjBweDtib3JkZXItcmFkaXVzOjNweDtjb2xvcjojZmZmO2JhY2tncm91bmQ6IzAwYWZlZTtkaXNwbGF5OmlubGluZS1ibG9ja311bC5nbGlkZV9fc2xpZGVze21hcmdpbjowfQ==
LnRiLWhlYWRpbmcuaGFzLWJhY2tncm91bmR7cGFkZGluZzowfQ==
Um9ib3RvOnJlZ3VsYXIsNzAwLDMwMA==
 .tb-container .tb-container-inner{width:100%;margin:0 auto} .wp-block-toolset-blocks-container.tb-container[data-toolset-blocks-container="e61a64d295706b5905bc3be92ed86e4b"] { border-radius: 8px;background: rgba( 243, 242, 242, 1 );padding: 48px; } .tb-grid,.tb-grid>.block-editor-inner-blocks>.block-editor-block-list__layout{display:grid;grid-row-gap:25px;grid-column-gap:25px}.tb-grid-item{background:#d38a03;padding:30px}.tb-grid-column{flex-wrap:wrap}.tb-grid-column>*{width:100%}.tb-grid-column.tb-grid-align-top{width:100%;display:flex;align-content:flex-start}.tb-grid-column.tb-grid-align-center{width:100%;display:flex;align-content:center}.tb-grid-column.tb-grid-align-bottom{width:100%;display:flex;align-content:flex-end} .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="83e4f9368be67e17ef7cf73b12562c1d"] { grid-template-columns: minmax(0, 0.735fr) minmax(0, 0.265fr);grid-column-gap: 76px;grid-row-gap: 0px;grid-auto-flow: row } .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="83e4f9368be67e17ef7cf73b12562c1d"] > .tb-grid-column:nth-of-type(2n + 1) { grid-column: 1 } .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="83e4f9368be67e17ef7cf73b12562c1d"] > .tb-grid-column:nth-of-type(2n + 2) { grid-column: 2 } .wp-block-toolset-blocks-grid-column.tb-grid-column[data-toolset-blocks-grid-column="9b97cf110b220d9fa39ed332dd9a6f8c"] { margin-left: 4px;display: flex; } .wp-block-toolset-blocks-grid-column.tb-grid-column[data-toolset-blocks-grid-column="9b97cf110b220d9fa39ed332dd9a6f8c"] p { line-height: 3px; } .tb-field[data-toolset-blocks-field="dfa6bb20d23ade5d44128037c2087b7d"] { font-size: 13px;font-family: Roboto;font-weight: regular;line-height: 16px; }  .tb-field[data-toolset-blocks-field="31537f64838810a0b8f9030d23a1eebd"] { font-size: 13px;font-family: Roboto;font-weight: regular;line-height: 16px;padding-bottom: 6px; }  .tb-field[data-toolset-blocks-field="1486cee24b651bcac937c79e6155c9bf"] { font-size: 13px;font-family: Roboto;font-weight: regular;line-height: 16px;padding-bottom: 6px; }  .tb-field[data-toolset-blocks-field="24bd4910ab3d07fdd44f628d9947393a"] { font-size: 13px;font-family: Roboto;font-weight: regular;line-height: 16px;padding-bottom: 6px; }  .tb-field[data-toolset-blocks-field="031c5e5a15849a827dcb09445b9564dd"] { font-size: 13px;font-family: Roboto;font-weight: regular;line-height: 16px;padding-bottom: 6px; }  .tb-field[data-toolset-blocks-field="4b115832581cb6288c620bbff21fb844"] { font-size: 13px;font-family: Roboto;font-weight: regular;line-height: 16px;padding-top: 0px;padding-bottom: 6px;margin-top: 0px; }  .tb-field[data-toolset-blocks-field="29d76ce207d419a012efb65b8acefd03"] { font-size: 13px;font-family: Roboto;font-weight: regular;line-height: 16px;padding-top: 0px;padding-bottom: 6px;margin-top: 0px; }  h4.tb-heading[data-toolset-blocks-heading="aad2c857f9e298945c7ae5d9c5c8c480"]  { font-size: 22px;font-family: Roboto;font-weight: 300;line-height: 24px; }  .tb-button{color:#f1f1f1}.tb-button--left{text-align:left}.tb-button--center{text-align:center}.tb-button--right{text-align:right}.tb-button__link{color:inherit;cursor:pointer;display:inline-block;line-height:100%;text-decoration:none !important;text-align:center;transition:all 0.3s ease}.tb-button__link:hover,.tb-button__link:focus,.tb-button__link:visited{color:inherit}.tb-button__link:hover .tb-button__content,.tb-button__link:focus .tb-button__content,.tb-button__link:visited .tb-button__content{font-family:inherit;font-style:inherit;font-weight:inherit;letter-spacing:inherit;text-decoration:inherit;text-shadow:inherit;text-transform:inherit}.tb-button__content{vertical-align:middle;transition:all 0.3s ease}.tb-button__icon{transition:all 0.3s ease;display:inline-block;vertical-align:middle;font-style:normal !important}.tb-button__icon::before{content:attr(data-font-code);font-weight:normal !important}.tb-button__link{background-color:#444;border-radius:0.3em;font-size:1.3em;margin-bottom:0.76em;padding:0.55em 1.5em 0.55em} .tb-button[data-toolset-blocks-button="c96b78e58d378dbd8572eea39aeff915"] { text-align: left; } .tb-button[data-toolset-blocks-button="c96b78e58d378dbd8572eea39aeff915"] .tb-button__link { background-color: rgba( 139, 183, 8, 1 );margin-top: 12px;margin-bottom: 24px;font-size: 14px;font-family: Roboto;font-weight: regular; } .tb-field[data-toolset-blocks-field="199679b582a458bcd9da749881546784"] { font-size: 14px;font-family: Roboto;font-weight: regular;line-height: 18px;color: rgba( 47, 59, 64, 1 ); }  .tb-field[data-toolset-blocks-field="32489777632b4dbb178ccac5bcec8fc9"] { font-size: 14px;font-family: Roboto;font-weight: regular;line-height: 18px;color: rgba( 47, 59, 64, 1 ); }  .tb-field[data-toolset-blocks-field="9dab8c396297b53312f204b873cdf568"] { font-size: 22px;font-family: Roboto;font-weight: 300;line-height: 24px; }  .wp-block-toolset-blocks-grid-column.tb-grid-column[data-toolset-blocks-grid-column="3034fbe886c11054e95b46b09d3e4112"] { display: flex; } .tb-field[data-toolset-blocks-field="a75a43dc56a7b3852ec5dea68af8c8f5"] { font-size: 16px;font-family: Roboto;font-weight: 700;line-height: 18px;text-transform: uppercase;text-align: initial;color: rgba( 139, 183, 8, 1 ); }  .tb-field[data-toolset-blocks-field="4ed92c8c217915fc11adfd6dd309d904"] { font-size: 36px;font-family: Roboto;font-weight: regular;line-height: 38px;text-align: left;color: rgba( 0, 113, 137, 1 ); }  @media only screen and (max-width: 781px) {  .tb-container .tb-container-inner{width:100%;margin:0 auto}.tb-grid,.tb-grid>.block-editor-inner-blocks>.block-editor-block-list__layout{display:grid;grid-row-gap:25px;grid-column-gap:25px}.tb-grid-item{background:#d38a03;padding:30px}.tb-grid-column{flex-wrap:wrap}.tb-grid-column>*{width:100%}.tb-grid-column.tb-grid-align-top{width:100%;display:flex;align-content:flex-start}.tb-grid-column.tb-grid-align-center{width:100%;display:flex;align-content:center}.tb-grid-column.tb-grid-align-bottom{width:100%;display:flex;align-content:flex-end} .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="83e4f9368be67e17ef7cf73b12562c1d"] { grid-template-columns: minmax(0, 0.5fr) minmax(0, 0.5fr);grid-auto-flow: row } .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="83e4f9368be67e17ef7cf73b12562c1d"] > .tb-grid-column:nth-of-type(2n + 1) { grid-column: 1 } .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="83e4f9368be67e17ef7cf73b12562c1d"] > .tb-grid-column:nth-of-type(2n + 2) { grid-column: 2 } .wp-block-toolset-blocks-grid-column.tb-grid-column[data-toolset-blocks-grid-column="9b97cf110b220d9fa39ed332dd9a6f8c"] { display: flex; }         .tb-button{color:#f1f1f1}.tb-button--left{text-align:left}.tb-button--center{text-align:center}.tb-button--right{text-align:right}.tb-button__link{color:inherit;cursor:pointer;display:inline-block;line-height:100%;text-decoration:none !important;text-align:center;transition:all 0.3s ease}.tb-button__link:hover,.tb-button__link:focus,.tb-button__link:visited{color:inherit}.tb-button__link:hover .tb-button__content,.tb-button__link:focus .tb-button__content,.tb-button__link:visited .tb-button__content{font-family:inherit;font-style:inherit;font-weight:inherit;letter-spacing:inherit;text-decoration:inherit;text-shadow:inherit;text-transform:inherit}.tb-button__content{vertical-align:middle;transition:all 0.3s ease}.tb-button__icon{transition:all 0.3s ease;display:inline-block;vertical-align:middle;font-style:normal !important}.tb-button__icon::before{content:attr(data-font-code);font-weight:normal !important}.tb-button__link{background-color:#444;border-radius:0.3em;font-size:1.3em;margin-bottom:0.76em;padding:0.55em 1.5em 0.55em}   .wp-block-toolset-blocks-grid-column.tb-grid-column[data-toolset-blocks-grid-column="3034fbe886c11054e95b46b09d3e4112"] { display: flex; }    } @media only screen and (max-width: 599px) {  .tb-container .tb-container-inner{width:100%;margin:0 auto}.tb-grid,.tb-grid>.block-editor-inner-blocks>.block-editor-block-list__layout{display:grid;grid-row-gap:25px;grid-column-gap:25px}.tb-grid-item{background:#d38a03;padding:30px}.tb-grid-column{flex-wrap:wrap}.tb-grid-column>*{width:100%}.tb-grid-column.tb-grid-align-top{width:100%;display:flex;align-content:flex-start}.tb-grid-column.tb-grid-align-center{width:100%;display:flex;align-content:center}.tb-grid-column.tb-grid-align-bottom{width:100%;display:flex;align-content:flex-end} .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="83e4f9368be67e17ef7cf73b12562c1d"] { grid-template-columns: minmax(0, 1fr);grid-auto-flow: row } .wp-block-toolset-blocks-grid.tb-grid[data-toolset-blocks-grid="83e4f9368be67e17ef7cf73b12562c1d"]  > .tb-grid-column:nth-of-type(1n+1) { grid-column: 1 } .wp-block-toolset-blocks-grid-column.tb-grid-column[data-toolset-blocks-grid-column="9b97cf110b220d9fa39ed332dd9a6f8c"] { display: flex; }         .tb-button{color:#f1f1f1}.tb-button--left{text-align:left}.tb-button--center{text-align:center}.tb-button--right{text-align:right}.tb-button__link{color:inherit;cursor:pointer;display:inline-block;line-height:100%;text-decoration:none !important;text-align:center;transition:all 0.3s ease}.tb-button__link:hover,.tb-button__link:focus,.tb-button__link:visited{color:inherit}.tb-button__link:hover .tb-button__content,.tb-button__link:focus .tb-button__content,.tb-button__link:visited .tb-button__content{font-family:inherit;font-style:inherit;font-weight:inherit;letter-spacing:inherit;text-decoration:inherit;text-shadow:inherit;text-transform:inherit}.tb-button__content{vertical-align:middle;transition:all 0.3s ease}.tb-button__icon{transition:all 0.3s ease;display:inline-block;vertical-align:middle;font-style:normal !important}.tb-button__icon::before{content:attr(data-font-code);font-weight:normal !important}.tb-button__link{background-color:#444;border-radius:0.3em;font-size:1.3em;margin-bottom:0.76em;padding:0.55em 1.5em 0.55em}   .wp-block-toolset-blocks-grid-column.tb-grid-column[data-toolset-blocks-grid-column="3034fbe886c11054e95b46b09d3e4112"] { display: flex; }    } 
STAT3 inhibition som immunterapi för behandling av prostatacancer
GLACTONE PHARMA DEVELOPMENT AB
Läkemedel STAT3 blockerande substans
STAT3 är ett protein som är överaktiverat vid olika typer av cancer vilket kan leda till okontrollerad tillväxt av tumörceller, behandlingsresistens och nedreglering av immunsystemet. Prekliniska studier med Glactones STAT3 blockerande substans har visat att den kan öka effekten av immunterapi. Projektets syfte var att identifiera de immunologiska mekanismerna vilka gör att STAT3 blockering ökar effekten av immunterapi och på så sätt generera kunskap och data som stödjer den fortsatta utvecklingen mot en klinisk användning.
PROJEKTFAKTA
KATEGORI:
Läkemedel
KOORDINATOR:
GLACTONE PHARMA DEVELOPMENT AB
PROJEKTNUMMER:
2018-00262
BIDRAG:
1 000 000 kr
STARTDATUM:
maj 28, 2018
SLUTDATUM:
juni 17, 2019
PROJEKTSTATUS:
Avslutade