Opening up markets by developing new formulation for osteoinductive biomaterial

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OSSDSIGN AB

OssDsign Catalyst nanosyntetisk bentransplantatputty är utformad för att engagera dubbla bilda benvägar för snabb och pålitlig benbildning vid tidiga tidpunkter genom hela fusionen.

Projektet syftade till att utveckla ett syntetiskt, biologiskt effektivt benersättningsmaterial, i form av en putty, för steloperationer i ryggen och utvärdera dess effekt i en etablerad pre-klinisk modell.

Huvudmålet med projektet som var att utveckla ett benersättningsmaterial har ej till fullo uppfyllts eftersom resultatet från den pre-klinisk studien inte gav det resultat vi hade förväntat oss dvs ingen fusion kunde påvisas för någon av de två testartiklarna (putty och granuler) som ingick i studien. Båda testartiklarna påvisade tydlig ben-nybildning och trots att huvudmålet inte har uppfyllts har vi dragit flera lärdomar från projektet om vilka materialparametrar som behöver optimeras; såsom mängdförhållande mellan granuler och polymer, form och storlek på granuler samt steriliseringens påverkan på polymerens hållbarhet över tid som i framtiden kommer kunna bidra till utvecklingen av en produkt för spinal fusion. Under projektet gång beslutade vi att istället för att genomföra den planerade osteoinduktions-studien i råtta istället utöka den pre-kliniska fusions-studien med ytterligare en testgrupp där vi då inkluderade rena kalciumfosfat granuler som blandades med blod. Gruppen bedömde att de resultaten var av mer värde än de som skulle genereras från induktionsstudien. Materialet har under tiden påvisats vara osteoinduktivt i får och således ansågs inte att studien på råtta skulle tillföra något ytterligare i detta skedet. I övrigt så har målet med att etablera att samarbete mellan OssDsign, Sahlgrenska och Uppsala Universitet uppfyllts där vi ser flertalet intressanta samarbeten i framtiden relaterat till OssDsigns unika material och dess tillämpning inom ortopedi.

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PROJEKTFAKTA

KATEGORI:

Biologiska material, Implantat

KOORDINATOR:

OSSDSIGN AB

PROJEKTNUMMER:

2017-04676

BIDRAG:

1 781 000 kr

STARTDATUM:

januari 2, 2018

SLUTDATUM:

november 15, 2020

PROJEKTSTATUS:

Avslutade

NY SÖKNING